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NIR-II reinforced intracellular cyclic reaction to enhance chemodynamic therapy with abundant H2O2 supply.
- Source :
-
Biomaterials . Aug2021, Vol. 275, pN.PAG-N.PAG. 1p. - Publication Year :
- 2021
-
Abstract
- Chemodynamic therapy (CDT) is an ideal therapeutic modality with endogenous H 2 O 2 as stimulus. Most intracellular H 2 O 2 supplement strategies for improving CDT efficiency are strongly rely on oxygen participation, and the hypoxia tumor microenvironment impairs their performance. Here we develop a self-assembled metal-organic coordinated nanoparticle Cu–OCNP/Lap with NIR-II reinforced intracellular cyclic reaction to enhance CDT efficiency. Cu–OCNP/Lap is synthesized using Cu2+ as nodes and 1,4,5,8-tetrahydroxyanthraquinone (THQ) and banoxantrone dihydrochloride (AQ4N) as ligands, with β-lapachone (β-Lap) loading to conduct intracellular cyclic reaction. Cu–OCNP/Lap has good photothermal effect at NIR-II window, and the corresponding local temperature increase speeds blood flow and supplies sufficient oxygen at tumor site to reinforce β-Lap cyclic reaction with abundant H 2 O 2 generation. Cu+ is released from Cu–OCNP/Lap in response to glutathione (GSH) and triggers CDT. Sufficient intracellular H 2 O 2 supply enhances CDT effect and demonstrates good suppressions for tumor growth. This design offers a promising strategy to enhance CDT efficiency. [Display omitted] [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01429612
- Volume :
- 275
- Database :
- Academic Search Index
- Journal :
- Biomaterials
- Publication Type :
- Academic Journal
- Accession number :
- 151608270
- Full Text :
- https://doi.org/10.1016/j.biomaterials.2021.120962