NIR-II reinforced intracellular cyclic reaction to enhance chemodynamic therapy with abundant H2O2 supply.

Chemodynamic therapy (CDT) is an ideal therapeutic modality with endogenous H 2 O 2 as stimulus. Most intracellular H 2 O 2 supplement strategies for improving CDT efficiency are strongly rely on oxygen participation, and the hypoxia tumor microenvironment impairs their performance. Here we develop a self-assembled metal-organic coordinated nanoparticle Cu–OCNP/Lap with NIR-II reinforced intracellular cyclic reaction to enhance CDT efficiency. Cu–OCNP/Lap is synthesized using Cu2+ as nodes and 1,4,5,8-tetrahydroxyanthraquinone (THQ) and banoxantrone dihydrochloride (AQ4N) as ligands, with β-lapachone (β-Lap) loading to conduct intracellular cyclic reaction. Cu–OCNP/Lap has good photothermal effect at NIR-II window, and the corresponding local temperature increase speeds blood flow and supplies sufficient oxygen at tumor site to reinforce β-Lap cyclic reaction with abundant H 2 O 2 generation. Cu+ is released from Cu–OCNP/Lap in response to glutathione (GSH) and triggers CDT. Sufficient intracellular H 2 O 2 supply enhances CDT effect and demonstrates good suppressions for tumor growth. This design offers a promising strategy to enhance CDT efficiency. [Display omitted] [ABSTRACT FROM AUTHOR]