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Persistence of GLP-1 RA in combination with basal insulin among adults with type 2 diabetes in Canada.
- Source :
-
Diabetes Research & Clinical Practice . Jul2021, Vol. 177, pN.PAG-N.PAG. 1p. - Publication Year :
- 2021
-
Abstract
- <bold>Aims: </bold>The purpose of this study is to assess the persistence of Canadians with Type 2 diabetes mellitus (T2D) on loose-dose combination treatment (i.e., administered by separate devices) with a glucagon-like peptide 1 receptor agonist (GLP-1 RA) and basal insulin over 12 months.<bold>Methods: </bold>This study is a retrospective cohort study of T2D adults using a Canadian longitudinal prescription database over a 5-year period. Cohort 1 (n = 12,411) is a primary cohort including only individuals inexperienced with the combination therapy at index. Cohort 2 (n = 13,498) is an exploratory cohort and includes everyone regardless of previous experience on the loose-dose combination therapy. The primary endpoint is the proportion of individuals persistent and average days persistent to the loose-dose combination therapy at 12 months in Canada.<bold>Results: </bold>In Cohort 1, overall persistence was 47% in the 12-month period post-index. Persistence is similar when including all inexperienced and subsequent loose-dose combination experiences in Cohort 2 (45%).<bold>Conclusions: </bold>Canadian T2D adults taking a loose-dose combination therapy of a GLP-1 RA and basal insulin had overall low persistence and lower than reports from previous studies of GLP-1 RA or basal insulin alone. Improving persistence to combination therapy with GLP-1 RA plus basal insulin is an important issue to explore in clinical practice. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ADULTS
*TYPE 2 diabetes
*GLUCAGON-like peptide 1
*INSULIN
*PEPTIDE receptors
Subjects
Details
- Language :
- English
- ISSN :
- 01688227
- Volume :
- 177
- Database :
- Academic Search Index
- Journal :
- Diabetes Research & Clinical Practice
- Publication Type :
- Academic Journal
- Accession number :
- 151684181
- Full Text :
- https://doi.org/10.1016/j.diabres.2021.108920