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Defining colchicine resistance/intolerance in patients with familial Mediterranean fever: a modified-Delphi consensus approach.
- Source :
-
Rheumatology . Aug2021, Vol. 60 Issue 8, p3799-3808. 10p. - Publication Year :
- 2021
-
Abstract
- Objectives Colchicine is the main treatment for FMF. Although a number of individuals with FMF are intolerant/resistant to colchicine, there is no standard definition of colchicine resistance/intolerance. We developed a set of evidence-based core statements defining colchicine resistance/intolerance in patients with FMF that may serve as a guide for clinicians and health authorities. Methods A set of statements was identified using a modified-Delphi consensus-based approach. The process involved development of an initial colchicine resistance/intolerance-related questionnaire derived from a systematic literature review. The questionnaire, which was completed by an international panel of 11 adult and paediatric rheumatologists with expertise in FMF, was analysed anonymously. The results informed draft consensus statements that were discussed by a round-table expert panel, using a nominal group technique to agree on the selection and wording of the final statements. Results Consensus among the panel was achieved on eight core statements defining colchicine resistance/intolerance in patients with FMF. A definition of resistance was agreed upon that included recurrent clinical attacks (average one or more attacks per month over a 3-month period) or persistent laboratory inflammation in between attacks. Other core statements recognize the importance of assessing treatment adherence, and the impact of active disease and intolerance to colchicine on quality of life. Conclusion Based on expert opinion, a set of evidence-based core statements defining colchicine resistance/intolerance in patients with FMF were identified to help guide clinicians and health authorities in the management of patients with FMF. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MEDICAL quality control
*CONSENSUS (Social sciences)
*ONLINE information services
*MEDICAL information storage & retrieval systems
*MEDICAL databases
*INFORMATION storage & retrieval systems
*INFLAMMATION
*SYSTEMATIC reviews
*GENETIC disorders
*DRUG resistance
*HEALTH outcome assessment
*QUALITY of life
*QUESTIONNAIRES
*COLCHICINE
*MEDLINE
*DELPHI method
Subjects
Details
- Language :
- English
- ISSN :
- 14620324
- Volume :
- 60
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 151741999
- Full Text :
- https://doi.org/10.1093/rheumatology/keaa863