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Association between MMP16 rs60298754 and clinical phenotypes of Parkinson's disease in southern Chinese.
- Source :
-
Neurological Sciences . Aug2021, Vol. 42 Issue 8, p3211-3215. 5p. 2 Charts. - Publication Year :
- 2021
-
Abstract
- Study objectives: The aim was to investigate the association between MMP16 rs60298754 and symptoms of Parkinson's disease (PD) in southern Chinese. Methods: Seven hundred forty-five PD patients were recruited in this study. All patients were evaluated by Brief Pain Inventory (BPI), Hamilton anxiety rating scale and Hamilton depression rating scale, 39-item Parkinson's disease Questionnaire (PDQ-39), and MDS—Unified PD Rating Scale (MDS-UPDRS). Symptoms were also recorded. Results: The difference of BPI and Parkinson's disease sleep scale (PDSS) between two groups was showed (BPI: MMP16 wildtypes: 14.73 ± 14.45; MMP16 carriers: 10.95 ± 10.67, p 0.002; PDSS: MMP16 wildtypes: 117.80 ± 21.45; MMP16 carriers: 108.40 ± 23.95, p < 0.001). The association of apathy, nocturia, and sensitive to light were found (apathy: p 0.001, OR: 0.49, 0.32—0.76; nocturia: p < 0.001, OR: 3.57, 1.90—7.26; sensitive to light: p < 0.001, OR: 3.99, 2.01—7.74). Conclusions: MMP16 rs60298754 was associated with the presence of apathy, pain, nocturia, and sensitive to light. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15901874
- Volume :
- 42
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Neurological Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 151760088
- Full Text :
- https://doi.org/10.1007/s10072-020-04894-5