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Predictors of Mild Cognitive Impairment Stability, Progression, or Reversion in the Lothian Birth Cohort 1936.
- Source :
-
Journal of Alzheimer's Disease . 2021, Vol. 80 Issue 1, p225-232. 8p. - Publication Year :
- 2021
-
Abstract
- <bold>Background: </bold>Mild cognitive impairment (MCI) describes a borderland between healthy cognition and dementia. Progression to and reversion from MCI is relatively common but more research is required to understand the factors affecting this fluidity and improve clinical care interventions.<bold>Objective: </bold>We explore these transitions in MCI status and their predictive factors over a six-year period in a highly-phenotyped longitudinal study, the Lothian Birth Cohort 1936.<bold>Methods: </bold>MCI status was derived in the LBC1936 at ages 76 (nā=ā567) and 82 years (nā=ā341) using NIA-AA diagnostic guidelines. Progressions and reversions between healthy cognition and MCI over the follow-up period were assessed. Multinomial logistic regression assessed the effect of various predictors on the likelihood of progressing, reverting, or maintaining cognitive status.<bold>Results: </bold>Of the 292 participants who completed both time points, 41 (14%) participants had MCI at T1 and 56 (19%) at T2. Over the follow-up period, 74%remained cognitively healthy, 12%transitioned to MCI, 7%reverted to healthy cognition, and 7%maintained their baseline MCI status. Findings indicated that membership of these transition groups was affected by age, cardiovascular disease, and number of depressive symptoms.<bold>Conclusion: </bold>Findings that higher baseline depressive symptoms increase the likelihood of reverting from MCI to healthy cognition indicate that there may be an important role for the treatment of depression for those with MCI. However, further research is required to identify prevention strategies for those at high risk of MCI and inform effective interventions that increase the likelihood of reversion to, and maintenance of healthy cognition. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MILD cognitive impairment
*FORECASTING
*CARDIOVASCULAR diseases
*COGNITION
*DEMENTIA
*MENTAL depression
*COGNITION disorders
*DISEASE progression
*RESEARCH
*RESEARCH methodology
*MEDICAL cooperation
*EVALUATION research
*NEUROPSYCHOLOGICAL tests
*COMPARATIVE studies
*AGE factors in disease
*LONGITUDINAL method
Subjects
Details
- Language :
- English
- ISSN :
- 13872877
- Volume :
- 80
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Alzheimer's Disease
- Publication Type :
- Academic Journal
- Accession number :
- 151820904
- Full Text :
- https://doi.org/10.3233/JAD-201282