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Paraoxonase 1, B Vitamins Supplementation, and Mild Cognitive Impairment.
- Source :
-
Journal of Alzheimer's Disease . 2021, Vol. 81 Issue 3, p1211-1229. 19p. - Publication Year :
- 2021
-
Abstract
- <bold>Background: </bold>Identification of modifiable risk factors that affect cognitive decline is important for the development of preventive and treatment strategies. Status of paraoxonase 1 (PON1), a high-density lipoprotein-associated enzyme, may play a role in the development of neurological diseases, including Alzheimer's disease.<bold>Objective: </bold>We tested a hypothesis that PON1 status predicts cognition in individuals with mild cognitive impairment (MCI).<bold>Methods: </bold>Individuals with MCI (n = 196, 76.8-years-old, 60% women) participating in a randomized, double-blind placebo-controlled trial (VITACOG) were assigned to receive a daily dose of folic acid (0.8 mg), vitamin B12 (0.5 mg) and B6 (20 mg) (n = 95) or placebo (n = 101) for 2 years. Cognition was analyzed by neuropsychological tests. Brain atrophy was quantified in a subset of participants (n = 168) by MRI. PON1 status, including PON1 Q192R genotype, was determined by quantifying enzymatic activity of PON1 using paraoxon and phenyl acetate as substrates.<bold>Results: </bold>In the placebo group, baseline phenylacetate hydrolase (PhAcase) activity of PON1 (but not paraoxonase activity or PON1 Q192R genotype) was significantly associated with global cognition (Mini-Mental State Examination, MMSE; Telephone Inventory for Cognitive Status-modified, TICS-m), verbal episodic memory (Hopkins Verbal Learning Test-revised: Total Recall, HVLT-TR; Delayed Recall, HVLT-DR), and attention/processing speed (Trail Making A and Symbol Digits Modalities Test, SDMT) at the end of study. In addition to PhAcase, baseline iron and triglycerides predicted MMSE, baseline fatty acids predicted SDMT, baseline anti-N-Hcy-protein autoantibodies predicted TICS-m, SDMT, Trail Making A, while BDNF V66M genotype predicted HVLT-TR and HVLT-DR scores at the end of study. B-vitamins abrogated associations of PON1 and other variables with cognition.<bold>Conclusion: </bold>PON1 is a new factor associated with impaired cognition that can be ameliorated by B-vitamins in individuals with MCI. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MILD cognitive impairment
*VITAMIN B complex
*DIETARY supplements
*PARAOXONASE
*PHENYLACETATES
*THERAPEUTIC use of folic acid
*THERAPEUTIC use of vitamin B12
*BRAIN
*RESEARCH
*VITAMIN B12
*VITAMIN B6
*RESEARCH methodology
*COGNITION
*MAGNETIC resonance imaging
*MEDICAL cooperation
*EVALUATION research
*NEUROPSYCHOLOGICAL tests
*COMPARATIVE studies
*MASS spectrometry
*BLIND experiment
*ESTERASES
*FOLIC acid
Subjects
Details
- Language :
- English
- ISSN :
- 13872877
- Volume :
- 81
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Alzheimer's Disease
- Publication Type :
- Academic Journal
- Accession number :
- 151821121
- Full Text :
- https://doi.org/10.3233/JAD-210137