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Copper/silver co-mediated three-component bicyclization for accessing indeno[1,2-c]azepine-3,6-diones.
- Source :
-
Chemical Communications . 8/18/2021, Vol. 57 Issue 64, p7966-7969. 4p. - Publication Year :
- 2021
-
Abstract
- A new copper/silver-co-mediated three-component bicyclization of benzene-linked 1,6-enynes with ICF2CO2Et with TMSN3 was reported, and used to produce a wide range of hitherto unreported difluorinated tetrahydroindeno[1,2-c]azepine-3,6-diones with moderate to good yields. The mechanistic pathway consists of radical-induced 1,6-addition–cyclization, oxidative addition, reductive elimination, nitrene insertion and N–O cleavage, resulting in continuous multiple bond-forming events including C–C and C–N bonds to build up a 6/5/7 tricyclic framework. [ABSTRACT FROM AUTHOR]
- Subjects :
- *OXIDATIVE addition
*SILVER
*COPPER
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 57
- Issue :
- 64
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 151841684
- Full Text :
- https://doi.org/10.1039/d1cc02973h