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Association between a genetic variant in scavenger receptor class B type 1 and its role on codon usage bias with increased risk of developing coronary artery disease.
- Source :
-
Clinical Biochemistry . Sep2021, Vol. 95, p60-65. 6p. - Publication Year :
- 2021
-
Abstract
- Coronary artery disease (CAD) as an important cause of morbidity and mortality globally. The scavenger receptor class B type 1 (SCARB1) plays an essential role in the reverse cholesterol transport. We have explored the association between a genetic variant, rs5888, in the SCARB1 gene with CAD and serum HDL-C levels. Patients were categorized into two groups' angiogram positive (>50% coronary stenosis) and angiogram negative (<50% coronary stenosis). Genotyping was carried out using polymerase chain reaction-amplification refractory mutation system. The association between the SNP rs5888 and serum HDL-C was analyzed using a logistic regression model. The results showed that the subjects carrying a T allele was associated with a decreased serum HDL-C levels compared to the C allele in total population (p < 0.001). The risk of angiogram positivity in subjects carrying a T allele was 3.1-fold higher than for the control group (p < 0.001). CVD patients carrying the T allele of rs5888 variant in the SCARB1 gene was associated with decreased serum level of HDL. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00099120
- Volume :
- 95
- Database :
- Academic Search Index
- Journal :
- Clinical Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 151913365
- Full Text :
- https://doi.org/10.1016/j.clinbiochem.2021.06.001