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Response to Veitia et al.
- Source :
-
EMBO Journal . 8/16/2021, Vol. 40 Issue 16, p1-3. 3p. - Publication Year :
- 2021
-
Abstract
- GLO:1VT/16aug21:embj2021108671-toc-0001.jpg PHOTO (COLOR): . gl Previously, we provided experimental evidence demonstrating the discriminative miRNA targeting of a mutated site within the coding sequence of a variant allele (c.402C>G; p.C134W) of the tumor-suppressor gene I FOXL2 i that results in lower expression levels of the variant I FOXL2 i mRNA (Shin I et al i , 2020). Our I in vivo i genome-editing results clearly demonstrate that miR-1236 is an endogenous functional miRNA that specifically downregulates variant I FOXL2 i mRNA (Shin I et al i , 2020). We disagree with the claims of Veitia I et al i based on the simple interpretation of the height of the electropherograms obtained from the Sanger sequencing analysis (fig 1of Veitia I et al i ). [Extracted from the article]
- Subjects :
- *DNA sequencing
*GRANULOSA cell tumors
*RNA sequencing
Subjects
Details
- Language :
- English
- ISSN :
- 02614189
- Volume :
- 40
- Issue :
- 16
- Database :
- Academic Search Index
- Journal :
- EMBO Journal
- Publication Type :
- Academic Journal
- Accession number :
- 151931813
- Full Text :
- https://doi.org/10.15252/embj.2021108671