Back to Search
Start Over
Reactivity and Selectivity Principles in Native Protein Bioconjugation.
- Source :
-
Chemical Record . Aug2021, Vol. 21 Issue 8, p1941-1956. 16p. - Publication Year :
- 2021
-
Abstract
- Are chemical methods capable of precisely engineering the native proteins? Is it possible to develop platforms that can empower the regulation of chemoselectivity, site‐selectivity, modularity, protein‐specificity, and site‐specificity? This account delineates our research journey in the last ten years on the developments revolving around these questions. It will range from the realization of chemoselective and site‐selective labeling of reactivity hotspots to modular linchpin directed modification (LDM®) platform and site‐specific Gly‐tag® technology. Also, we outline a few biotechnology tools, including Maspecter®, that accelerated the detailed analysis of the bioconjugates and rendered a powerful toolbox for homogeneous antibody‐drug conjugates (ADCs). [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15278999
- Volume :
- 21
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Chemical Record
- Publication Type :
- Academic Journal
- Accession number :
- 151932717
- Full Text :
- https://doi.org/10.1002/tcr.202100108