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Potential Novel Genes for Late-Onset Alzheimer's Disease in East-Asian Descent Identified by APOE-Stratified Genome-Wide Association Study.
- Source :
-
Journal of Alzheimer's Disease . 2021, Vol. 82 Issue 4, p1451-1460. 10p. - Publication Year :
- 2021
-
Abstract
- The present study reports two novel genome-wide significant loci for late-onset Alzheimer's disease (LOAD) identified from APOE ε4 non-carrier subjects of East Asian origin. A genome-wide association study of Alzheimer's disease was performed in 2,291 Korean seniors in the discovery phase, from the Gwangju Alzheimer' and Related Dementias (GARD) cohort study. The study was replicated in a Japanese cohort of 1,956 subjects that suggested two novel susceptible SNPs in two genes: LRIG1 and CACNA1A. This study demonstrates that the discovery of AD-associated variants is feasible in non-European ethnic groups using samples comprising fewer subjects from the more homogeneous genetic background. [ABSTRACT FROM AUTHOR]
- Subjects :
- *GENOME-wide association studies
*ALZHEIMER'S disease
*OLDER people
*ETHNIC groups
*GENES
*RESEARCH
*SEQUENCE analysis
*RESEARCH methodology
*GENETIC polymorphisms
*MEDICAL cooperation
*EVALUATION research
*MEMBRANE glycoproteins
*COMPARATIVE studies
*APOLIPOPROTEINS
*RESEARCH funding
*CALCIUM
*LONGITUDINAL method
Subjects
Details
- Language :
- English
- ISSN :
- 13872877
- Volume :
- 82
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of Alzheimer's Disease
- Publication Type :
- Academic Journal
- Accession number :
- 151949918
- Full Text :
- https://doi.org/10.3233/JAD-210145