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Bench‐Stable Electrophilic Fluorinating Reagents for Highly Selective Mono‐ and Difluorination of Silyl Enol Ethers.
- Source :
-
Chemistry - A European Journal . 8/16/2021, Vol. 27 Issue 46, p11919-11925. 7p. - Publication Year :
- 2021
-
Abstract
- Efficient methods for the synthesis of fluorinated compounds have been intensively studied, recently. Development of practical fluorinating reagents is indispensable for this purpose. Herein, bench‐stable electrophilic fluorinating reagents were synthesized as N‐fluorobenzenesulfonimide (NFSI) substitutes. Reagents obtained by replacing one of the NFSI sulfonyl groups with an acyl group led to the highly selective monofluorination of silyl enol ethers with suppression of undesired overreaction, that is, difluorination. On the other hand, reagents bearing electron‐withdrawing substituents at NFSI benzenesulfonyl groups efficiently facilitated the difluorination of silyl enol ethers under base‐free conditions. Thus, both mono‐ and difluorinated target materials were prepared from the same substrate. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SILYL enol ethers
*ELECTROPHILES
*ACYL group
*SULFONYL group
Subjects
Details
- Language :
- English
- ISSN :
- 09476539
- Volume :
- 27
- Issue :
- 46
- Database :
- Academic Search Index
- Journal :
- Chemistry - A European Journal
- Publication Type :
- Academic Journal
- Accession number :
- 151958887
- Full Text :
- https://doi.org/10.1002/chem.202101499