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Tertiary cyclopropyl carbagermatranes: synthesis and cross-coupling.
- Source :
-
Chemical Communications . 8/25/2021, Vol. 57 Issue 66, p8143-8146. 4p. - Publication Year :
- 2021
-
Abstract
- The construction of the cyclopropyl quaternary carbon center can afford a series of 1,1-olefin bioisosteres. Here, we report tertiary cyclopropyl carbagermatranes, which can be easily obtained by the zinc-mediated decarboxylation of NHP esters. In addition, they exhibit efficient reactivity in the palladium-catalyzed cross-coupling reaction and orthogonal reactivity with boron reagents, therefore acting as robust nucleophiles for the synthesis of tertiary cyclopropane and efficient intermediates for the formation of quaternary centers. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BIOISOSTERES
*CYCLOPROPANE
*NUCLEOPHILES
*DECARBOXYLATION
*ESTERS
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 57
- Issue :
- 66
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 151959064
- Full Text :
- https://doi.org/10.1039/d1cc02930d