Sensitive imaging of tumors using a nitroreductase-activated fluorescence probe in the NIR-II window.

A nitroreductase (NTR)-activated NIR-II fluorescence probe for tumor imaging is reported. The probe can emit fluorescence in the range of 900–1300 nm, and target hypoxic tumors with NTR overexpression, thus allowing for accurate delineation of tumor margins through deep penetration. [ABSTRACT FROM AUTHOR]