Synthesis, Structure Elucidation, and Pharmacological Study of New Hydrazinylidene Derivatives Using Benzimidazole as a Scaffold.

New hydrazinylidene derivatives were synthesized under appropriate conditions and in excellent yields, by the reaction between a new [1,3]thiazolo[3,2-a]benzimidazol-2(3H)-one substrate and a series of aryldiazonium salts bearing groups with different electronic effect. The structures of the synthesized compounds were verified by FT-IR, 1H NMR and mass spectra. The pharmacological study including determining antimicrobial activity, cytotoxicity LD50 and histological study for compound ethyl 4-[(2Z)-2-(2-oxo[1,3]thiazolo[3,2-a] benzimidazol-3(2H)-ylidene)hydrazinyl]benzoate have been fulfilled. All chemical and biological result show possibility of using the compound ethyl 4-[(2Z)-2-(2-oxo[1,3]thiazolo[3,2-a] benzimidazol-3(2H)-ylidene)hydrazinyl]benzoate as a new topical antibiotic. [ABSTRACT FROM AUTHOR]