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Prognostic value of olfactory evoked potentials in patients with post-infectious olfactory dysfunction.
- Source :
-
European Archives of Oto-Rhino-Laryngology . Oct2021, Vol. 278 Issue 10, p3839-3846. 8p. - Publication Year :
- 2021
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Abstract
- Purpose: Prognostic assessment of patients with post-infectious olfactory dysfunction (PIOD) poses a challenge for clinicians. While there have been some studies on the prognostic factors of PIOD focusing on demographic factors, the aim of this study was to investigate whether event-related potentials (ERPs) could be used as a new predictor of olfactory recovery in PIOD. Methods: This was a retrospective study involving patients who underwent olfactory examinations using Sniffin' Sticks test before treatment and after 1 year of follow-up. The responder group was defined by an increase of threshold–discrimination–identification (TDI) score of ≥ 6 points. All patients underwent ERP examination and the amplitude and latency of each wave of ERPs were recorded before treatment. Results: A total of 61 patients (age 47.50 ± 11.04 years, 27 males) were analyzed. The presence of olfactory ERPs (oERPs) was greater in the responder group than in the non-responder group (P = 0.007), while that of trigeminal ERPs (tERPs) did not differ between the two groups (P = 0.346). Logistic-regression analyses showed that factors associated with improvement of subjective olfactory function were duration (OR, 1.604; 95% CI, 1.062–2.423; P = 0.025), initial threshold (odds ratio [OR], 0.043; 95% confidence interval [CI], 0.004–0.439; P = 0.008), and latency of N1 in oERPs (OR, 1.007; 95% CI, 1.001–1.013; P = 0.021). Conclusion: Our study shows that duration of OD, initial threshold, and latency of N1 in oERPs were associated with olfactory improvement in PIOD patients, which may provide guidance for clinicians. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09374477
- Volume :
- 278
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- European Archives of Oto-Rhino-Laryngology
- Publication Type :
- Academic Journal
- Accession number :
- 152043843
- Full Text :
- https://doi.org/10.1007/s00405-021-06683-y