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Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T-cell memory formation after mild COVID-19 infection.
- Source :
-
eLife . 1/13/2021, p1-17. 17p. - Publication Year :
- 2021
-
Abstract
- COVID-19 is a global pandemic caused by the SARS-CoV-2 coronavirus. T cells play a key role in the adaptive antiviral immune response by killing infected cells and facilitating the selection of virus-specific antibodies. However, neither the dynamics and cross-reactivity of the SARS-CoV-2-specific T-cell response nor the diversity of resulting immune memory is well understood. In this study, we use longitudinal high-throughput T-cell receptor (TCR) sequencing to track changes in the T-cell repertoire following two mild cases of COVID-19. In both donors, we identified CD4+ and CD8+ T-cell clones with transient clonal expansion after infection. We describe characteristic motifs in TCR sequences of COVID-19-reactive clones and show preferential occurrence of these motifs in publicly available large dataset of repertoires from COVID-19 patients. We show that in both donors, the majority of infection-reactive clonotypes acquire memory phenotypes. Certain T-cell clones were detected in the memory fraction at the pre- infection time point, suggesting participation of pre-existing cross-reactive memory T cells in the immune response to SARS-CoV-2. [ABSTRACT FROM AUTHOR]
- Subjects :
- *COVID-19
*COVID-19 pandemic
*IMMUNOLOGIC memory
*SARS-CoV-2
*T cells
*MEMORY
Subjects
Details
- Language :
- English
- ISSN :
- 2050084X
- Database :
- Academic Search Index
- Journal :
- eLife
- Publication Type :
- Academic Journal
- Accession number :
- 152077753
- Full Text :
- https://doi.org/10.7554/eLife.63502