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TEMPO‐Mediated Selective Synthesis of Isoxazolines, 5‐Hydroxy‐2‐isoxazolines, and Isoxazoles via Aliphatic δ‐C(sp3)‐H Bond Oxidation of Oximes.
- Source :
-
Chemistry - An Asian Journal . Sep2021, Vol. 16 Issue 17, p2439-2446. 8p. - Publication Year :
- 2021
-
Abstract
- Selective synthesis of three different bioactive heterocycles; isoxazolines, 5‐hydroxy‐2‐isoxazolines and isoxazoles from the same starting material using TEMPO (2,2,6,6‐Tetramethylpiperidin‐1‐oxyl) as a radical initiator is reported. Selectivity was achieved using different oxidants with TEMPO. The reaction goes through a 1,5‐HAT (hydrogen atom transfer) process resulting in products with good yields. This strategy offers a straightforward route to three different heterocycles from oximes via radical‐mediated C(sp3)‐H oxidation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 18614728
- Volume :
- 16
- Issue :
- 17
- Database :
- Academic Search Index
- Journal :
- Chemistry - An Asian Journal
- Publication Type :
- Academic Journal
- Accession number :
- 152209359
- Full Text :
- https://doi.org/10.1002/asia.202100572