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An efficient transition-metal-free route to quinazolin-4(3H)-ones via 2-aminobenzamides and thiols.
- Source :
-
New Journal of Chemistry . 9/14/2021, Vol. 45 Issue 34, p15344-15349. 6p. - Publication Year :
- 2021
-
Abstract
- An efficient approach to quinazolin-4(3H)-ones was developed by a one-pot intermolecular annulation reaction of o-amino benzamides and thiols. This method has the features of good functional group tolerance, being transition metal and external oxidant free, and easy operation. Varieties of 2-aryl (heteroaryl) quinazolin-4(3H)-one, 2-phenyl-pyrido[2,3-d]pyrimidin-4(3H)-one and 3-phenyl-2H-1,2,4-benzo thiadiazine-1,1-dioxide derivatives were obtained with a yield of up to 98%. The control experiment revealed that the thiol substrate could promote the dehydroaromatization step. [ABSTRACT FROM AUTHOR]
- Subjects :
- *TRANSITION metals
*BENZAMIDE
*FUNCTIONAL groups
*ANNULATION
*OXIDIZING agents
Subjects
Details
- Language :
- English
- ISSN :
- 11440546
- Volume :
- 45
- Issue :
- 34
- Database :
- Academic Search Index
- Journal :
- New Journal of Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 152224391
- Full Text :
- https://doi.org/10.1039/d1nj03179a