Functional reorganization of brain regions into a network in childhood absence epilepsy: A magnetoencephalography study.

• Significant brain areas are re-combined to form an epilepsy network in CAE. • Multi-focal source activity may indicate more brain areas are involved in seizures. • Imaging findings may provide a reference for clinical characteristics. Epilepsy is considered as a network disorder. However, it is unknown how normal brain activity develops into the highly synchronized discharging activity seen in disordered networks. This study aimed to explore the epilepsy brain network and the significant re-combined brain areas in childhood absence epilepsy (CAE). Twenty-two children with CAE were recruited to study the neural source activity during ictal-onset and interictal periods at frequency bands of 1–30 Hz and 30–80 Hz with magnetoencephalography (MEG) scanning. Accumulated source imaging (ASI) was used to analyze the locations of neural source activity and peak source strength. Most of the participants had more active source activity locations in the ictal-onset period rather than in the interictal period, both at 1–30 Hz and 30–80 Hz. The frontal lobe (FL), the temporo-parietal junction (T-P), and the parietal lobe (PL) became the main active areas of source activity during the ictal period, while the precuneus (PC), cuneus, and thalamus were relatively inactive. Some brain areas become more excited and have increased source activity during seizures. These significant brain regions might be re-combined to form an epilepsy network that regulates the process of absence seizures. The study confirmed that important brain regions are reorganized in an epilepsy network, which provides a basis for exploring the network mechanism of CAE development. Imaging findings may provide a reference for clinical characteristics. [ABSTRACT FROM AUTHOR]