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Anticancer properties of bisaminoquinolines with modified linkers.
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Oct2021, Vol. 49, pN.PAG-N.PAG. 1p. - Publication Year :
- 2021
-
Abstract
- [Display omitted] We have previously reported the unique features of dimeric bisaminoquinolines as anticancer agents and have identified their cellular target as PPT1, a protein palmitoyl-thioesterase. We now report a systematic study on the role of the linker in these constructs, both with respect to the distance between the heterocycles, the linker hydrophobicity and the methylation status (primary vs. secondary vs. tertiary) of the central nitrogen atom on the observed biological activity. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ANTINEOPLASTIC agents
*HETEROCYCLIC compounds
*METHYLATION
*PROTEINS
*QUINOLINE
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 49
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 152251829
- Full Text :
- https://doi.org/10.1016/j.bmcl.2021.128272