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Enantioselective Total Synthesis of Sacubitril.
- Source :
-
ChemistrySelect . 9/7/2021, Vol. 6 Issue 33, p8928-8930. 3p. - Publication Year :
- 2021
-
Abstract
- An efficient enantioselective approach of Sacubitril 1 (a NEP inhibitor) which is used as a combination drug with Valsartan to treat heart failure, is described. The synthesis features the Evan's asymmetric alkylation, Sharpless asymmetric diydroxylation (AD) and Heck coupling reactions as key steps. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ENTRESTO
*HECK reaction
*HEART failure
*DRUG utilization
*ALKYLATION
*NEPRILYSIN
Subjects
Details
- Language :
- English
- ISSN :
- 23656549
- Volume :
- 6
- Issue :
- 33
- Database :
- Academic Search Index
- Journal :
- ChemistrySelect
- Publication Type :
- Academic Journal
- Accession number :
- 152310556
- Full Text :
- https://doi.org/10.1002/slct.202102506