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Enantioselective Total Synthesis of Sacubitril.

Authors :
Kaur, Amanpreet
Gehlawat, Anju
Prakash, Ranjana
Pandey, Satyendra Kumar
Source :
ChemistrySelect. 9/7/2021, Vol. 6 Issue 33, p8928-8930. 3p.
Publication Year :
2021

Abstract

An efficient enantioselective approach of Sacubitril 1 (a NEP inhibitor) which is used as a combination drug with Valsartan to treat heart failure, is described. The synthesis features the Evan's asymmetric alkylation, Sharpless asymmetric diydroxylation (AD) and Heck coupling reactions as key steps. [ABSTRACT FROM AUTHOR]

Subjects

Subjects :
*ENTRESTO
*HECK reaction
*HEART failure
*DRUG utilization
*ALKYLATION
*NEPRILYSIN

Details

Language :
English
ISSN :
23656549
Volume :
6
Issue :
33
Database :
Academic Search Index
Journal :
ChemistrySelect
Publication Type :
Academic Journal
Accession number :
152310556
Full Text :
https://doi.org/10.1002/slct.202102506
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