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Inhibitory Effects of Bilirubin on Colonization and Migration of A431 and SK-MEL-3 Skin Cancer Cells Compared with Human Dermal Fibroblasts (HDF).
- Source :
-
Cancer Investigation . Oct2021, Vol. 39 Issue 9, p721-733. 13p. - Publication Year :
- 2021
-
Abstract
- This study evaluated the inhibitory effects of bilirubin on colony formation and cell migration of melanoma and non-melanoma skin cancer cell lines SK-MEL-3 and A431, compared with normal human dermal fibroblasts (HDF). The IC50 obtained from the MTT assay was 125, 100, and 75 μM bilirubin for HDF, A431, and SK-MEL-3 cells, respectively. The colony formation and cell migration of cancer cells, treated with 100 μM bilirubin, were reduced significantly (p < 0.05). Bilirubin decreased cell adhesion and inhibited cell colonization via inducing apoptosis and cell death. Also by interaction with migration main factors, bilirubin caused inhibition the cell migration. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HOST-bacteria relationships
*STATISTICS
*FIBROBLASTS
*ANALYSIS of variance
*MICRORNA
*SKIN tumors
*CELL motility
*GENE expression
*DESCRIPTIVE statistics
*CELL lines
*DATA analysis software
*DATA analysis
*POLYMERASE chain reaction
*BIOLOGICAL assay
*MOLECULAR structure
*BILIRUBIN
*CHEMICAL inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 07357907
- Volume :
- 39
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Cancer Investigation
- Publication Type :
- Academic Journal
- Accession number :
- 152466273
- Full Text :
- https://doi.org/10.1080/07357907.2021.1943428