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Cobalt‐Catalyzed Asymmetric 1,4‐Reduction of β,β‐Dialkyl α,β‐Unsaturated Esters with PMHS.
- Source :
-
European Journal of Organic Chemistry . 9/14/2021, Vol. 2021 Issue 34, p4861-4864. 4p. - Publication Year :
- 2021
-
Abstract
- A cobalt‐catalyzed asymmetric reduction of β,β‐dialkyl α,β‐unsaturated esters with polymethylhydrosiloxane (PMHS) was reported to deliver the corresponding esters containing a chiral trialkyl carbon center at β‐position with up to 97 % yield and 98 % ee. The chiral tridentate ligand oxazoline iminopyridine (OIP) could perform well for the asymmetric reduction instead of chiral bidentate ligands. This operationally simple protocol shows a broad scope of substrates using one equivalent of readily available PMHS as a cheap and easy‐to‐handle reductive reagent. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ESTERS
*OXAZOLINE
*LIGANDS (Chemistry)
*COBALT
*HYDROSILYLATION
*CARBON
Subjects
Details
- Language :
- English
- ISSN :
- 1434193X
- Volume :
- 2021
- Issue :
- 34
- Database :
- Academic Search Index
- Journal :
- European Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 152513553
- Full Text :
- https://doi.org/10.1002/ejoc.202100856