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Interleukin-17A (IL-17A): A silent amplifier of COVID-19.
- Source :
-
Biomedicine & Pharmacotherapy . Oct2021, Vol. 142, pN.PAG-N.PAG. 1p. - Publication Year :
- 2021
-
Abstract
- One of the hallmarks of COVID-19 is the cytokine storm that provokes primarily pneumonia followed by systemic inflammation. Emerging evidence has identified a potential link between elevated interleukin-17A (IL-17A) levels and disease severity and progression. Considering that per se, IL-17A can activate several inflammatory pathways, it is plausible to hypothesize an involvement of this cytokine in COVID-19 clinical outcomes. Thus, IL-17A could represent a marker of disease progression and/or a target to develop therapeutic strategies. This hypothesis paper aims to propose this "unique" cytokine as a silent amplifier of the COVID-19 immune response and (potentially) related therapy. [Display omitted] • One of the hallmarks of COVID-19 is the cytokine storm that provokes systemic inflammation. • Elevated levels of interleukin-17A (IL-17A) are associated to disease severity and progression. • We propose IL-17A as a silent amplifier of the COVID-19 immune response and (potentially) related therapy. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 07533322
- Volume :
- 142
- Database :
- Academic Search Index
- Journal :
- Biomedicine & Pharmacotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 152516637
- Full Text :
- https://doi.org/10.1016/j.biopha.2021.111980