Allicin ameliorates renal ischemia/reperfusion injury via inhibition of oxidative stress and inflammation in rats.

Allicin has been reported to play a biological role in human pathophysiological processes via interaction with numerous signaling pathways and gene expression alteration. The purpose of the present study was to evaluate the protective effects of allicin against renal ischemia/reperfusion injury (RIRI) in rats. In the present study, the RIRI model with 45-min ischemia and 22-h reperfusion in rats was generated and allicin was used as the intervention. Changes in renal tissue pathomorphology, renal function, oxidative stress, inflammatory response and apoptosis were evaluated in the RIRI model in rats. Compared with those in the RIRI group, renal function, renal pathological injury, and anti-inflammatory and antioxidant properties were markedly improved in the RIRI+allicin group. Thus, our research suggested that allicin exerted its protective effect against ischemia/reperfusion-induced renal injury by regulating apoptosis, oxidative stress and inflammatory response in rats. [Display omitted] • Pretreatment with allicin could regulate renal function impairment induced by ischemia reperfusion. • Preconditioning with allicin participated in oxidative stress of RIRI. • Allicin played a vital role in RIRI by exerting anti-apoptotic and anti-inflammatory activities. [ABSTRACT FROM AUTHOR]