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Oxidative stress, malaria, sickle cell disease, and innate immunity.
- Source :
-
Trends in Immunology . Oct2021, Vol. 42 Issue 10, p849-851. 3p. - Publication Year :
- 2021
-
Abstract
- Plasmodium falciparum shields from adaptive immunity in erythrocytes, but how might the innate immune system recognize infected cells? Replication by the parasite results in oxidative stress, causing surface expression of high-mannose glycans. These can act as pathogen-associated molecular patterns to stimulate phagocytosis in the spleen and the sickle cell allele enhances these responses. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SICKLE cell anemia
*OXIDATIVE stress
*NATURAL immunity
*MALARIA
*PHAGOCYTOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 14714906
- Volume :
- 42
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Trends in Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 152606867
- Full Text :
- https://doi.org/10.1016/j.it.2021.08.008