Back to Search
Start Over
Changes in Default Mode Network Connectivity in Resting-State fMRI in People with Mild Dementia Receiving Cognitive Stimulation Therapy.
- Source :
-
Brain Sciences (2076-3425) . Sep2021, Vol. 11 Issue 9, p1137-1137. 1p. - Publication Year :
- 2021
-
Abstract
- Group cognitive stimulation therapy (CST) is a 7-week activity-based non-pharmacological intervention for people with mild to moderate dementia. Despite consistent evidence of clinical efficacy, the cognitive and brain mechanisms of CST remain unclear. Theoretically, group CST as a person-centred approach may work through promoting social interaction and personhood, executive function, and language use, especially in people with higher brain/cognitive reserve. To explore these putative mechanisms, structural MRI and resting-state functional MRI data were collected from 16 people with mild dementia before and after receiving CST, and in 13 dementia controls who received treatment as usual (TAU). Voxel-based morphometry (VBM) and resting-state functional connectivity (rs-FC) analyses were performed. Compared with TAU, the CST group maintained the total brain volume/total intracranial volume (TBV/TICV) ratio. Increased rs-FC in the default mode network (DMN) in the posterior cingulate cortex and bilateral parietal cortices nodes was observed in the CST over TAU groups between pre- and post-intervention timepoints. We provided preliminary evidence that CST maintains/enhances brain reserve both structurally and functionally. Considering the role of DMN in episodic memory retrieval and mental self-representation, preservation of personhood may be an important mechanism of CST for further investigation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20763425
- Volume :
- 11
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Brain Sciences (2076-3425)
- Publication Type :
- Academic Journal
- Accession number :
- 152658186
- Full Text :
- https://doi.org/10.3390/brainsci11091137