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Evaluation of Cardiotoxic Effects of Anthracyclines by Tissue Doppler Imaging in Survivors of Childhood Cancer.
- Source :
-
Turkish Archives of Pediatrics . Sep2021, Vol. 56 Issue 5, p492-498. 7p. - Publication Year :
- 2021
-
Abstract
- Background: Childhood cancer survivors (CCSs) are at risk for anthracycline-induced cardio-toxicity which tends to be more prominent long after completion of the chemotherapy. The aim of this study was to examine echocardiographic parameters of anthracycline-induced subclinical cardiotoxicity in children who had received chemotherapy. Materials and Methods: A cross-sectional single-center study was conducted in a tertiary level university hospital in Eskisehir, Turkey. A total of 50 CCSs and 40 healthy peers were included. The CCSs were divided into 3 subgroups according to cumulative anthracycline dose (100-200 mg/m², 201-299 mg/m², and ≥ 300 mg/m²). Biventricular cardiac examination was performed with conventional echocardiography and tissue Doppler echocardiography imaging (TDI). Results: The mean duration from termination of chemotherapy to echocardiographic assessment was 3.9 ± 2.2 years. The mean age of the CCSs was 11.6 ± 3.9 years. TDI-derived mitral annular isovolumetric relaxation time (IVRT) and myocardial performance index (MPI) were higher in the high-dose group of CCSs than in controls (P = .006, P = .007, P < .001, P = .0014, respectively). IVRT was also higher in patients with ≥ 300 mg/m² cumulative dose than in those with < 200 mg/m² (P = .007). TDI-derived mitral annular MPI and IVRT were significantly associated with cumulative anthracycline dose (r = 0.288, P = .006, r = 0.340, P = .001). Conclusion: A cumulative anthracycline dose > 300 mg/m2 may lead to subclinical cardiotoxicity, and is therefore a potential risk factor for late onset cardiac failure. TDI-derived MPI can be a sensitive tool to reveal subtle signs of myocardial damage, which may facilitate implementation of preventive therapies for patients suspected to be at risk. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 27576256
- Volume :
- 56
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Turkish Archives of Pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 152661684
- Full Text :
- https://doi.org/10.5152/TurkArchPediatr.2021.20233