Increased platelet activation in SARS‐CoV‐2 infected non‐hospitalised children and adults, and their household contacts.

Increased platelet activation in SARS-CoV-2 infected non-hospitalised children and adults, and their household contacts Platelet activation and platelet-monocyte aggregates formation trigger tissue factor expression in severe COVID-19 patients. Keywords: platelet activation; Paediatrics; virology; flow cytometry; platelet function EN platelet activation Paediatrics virology flow cytometry platelet function 90 94 5 09/30/21 20211001 NES 211001 COVID-19 is associated with haemostatic dysregulation,1 with thromboembolism occurring in 25% of hospitalised COVID-19 patients and microvascular thrombi reported at autopsy.2 Platelets are activated in COVID-19 patients requiring intensive care,3 while limited data in mild COVID-19 shows no changes in platelet phenotype.4 Children have low-risk of severe COVID-19 and thrombosis.5 If haemostasis is fundamental to COVID-19 pathogenesis, then age-related haemostatic differences may protect children from COVID-19. Platelet activation, Paediatrics, virology, flow cytometry, platelet function. [Extracted from the article]