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Comparison of clinical characteristics in patients with acute zonal occult outer retinopathy according to anti-retinal antibody status.
- Source :
-
Graefe's Archive of Clinical & Experimental Ophthalmology . Oct2021, Vol. 259 Issue 10, p2967-2976. 10p. - Publication Year :
- 2021
-
Abstract
- Purpose: To evaluate the clinical characteristics of patients with acute zonal occult outer retinopathy (AZOOR), according to the presence or absence of anti-retinal antibodies (ARAs) that are frequently detected in autoimmune retinopathy. Methods: Retrospective observational case series. This study included 33 patients with acute-stage AZOOR who had been followed up for more than 6 months after the initial visit. The median follow-up period was 26 months. Immunoblot analyses were used to detect autoantibodies for recoverin, carbonic anhydrase II, and α-enolase in serum from these patients. Main outcome measures comprised clinical factors at the initial and final visits, including best-corrected visual acuity, mean deviation on Humphrey perimetry, and retinal morphology, which were statistically compared between patients with AZOOR who exhibited ARAs and those who did not. Results: At least one serum ARA was detected in 42% of patients with AZOOR. There were no significant differences in clinical factors between the two groups, including follow-up period, best-corrected visual acuity and mean deviation at the initial and final visits, a-wave amplitude on single-flash electroretinography at the initial visit, and frequencies of improvement of the macular ellipsoid zone and AZOOR recurrence. Conclusions: Our findings suggest that the presence of ARAs did not influence visual outcomes or outer retinal morphology in patients with AZOOR. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0721832X
- Volume :
- 259
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Graefe's Archive of Clinical & Experimental Ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 152677773
- Full Text :
- https://doi.org/10.1007/s00417-021-05198-w