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Tentative diagnostic criteria and disease severity classification for Castleman disease: A report of the research group on Castleman disease in Japan.

Authors :
Shino Fujimoto
Tomohiro Koga
Atsushi Kawakami
Hiroshi Kawabata
Shinichiro Okamoto
Masao Mizuki
Shingo Yano
Makoto Ide
Kazuko Uno
Katsumi Yagi
Toshiyuki Kojima
Minoru Mizutani
Yukihiro Tokumine
Norihiro Nishimoto
Hiroshi Fujiwara
Shin-ichi Nakatsuka
Kazuko Shiozawa
Noriko Iwaki
Yasufumi Masaki
Kazuyuki Yoshizaki
Source :
Modern Rheumatology. 2018, Vol. 28 Issue 1, p161-167. 7p.
Publication Year :
2018

Abstract

Objectives: To determine the tentative diagnostic criteria and disease severity classification for Castleman disease (CD) and describe the clinical and pathologic features among human herpesvirus 8 (HHV-8) negative idiopathic multicentric CD (iMCD) in the Japanese population. Methods: We established the working groups for the research of CD in Japan and had meetings to discuss and define the tentative diagnostic criteria and disease severity classification for CD. We subsequently analyzed 142 patients classified into iMCD by using the nationwide Japanese patient registry. Results: We proposed the preliminary diagnostic criteria and disease severity classification for CD based on our discussion. In addition, we made a proposal for the disease activity score. We identified clinical and pathological features of patients with iMCD diagnosed by these diagnostic criteria. In the disease severity classification, 37, 33 and 30% patients were categorized into mild, moderate and severe diseases, respectively. Conclusion: This is the first proposal for diagnosis and classification of CD by the Japanese group. Further studies are required to validate whether they can distinguish CD from other inflammatory diseases and to determine their sensitivity and specificity. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14397595
Volume :
28
Issue :
1
Database :
Academic Search Index
Journal :
Modern Rheumatology
Publication Type :
Academic Journal
Accession number :
152733183
Full Text :
https://doi.org/10.1080/14397595.2017.1366093