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Synthesis of High-Purity Basic Bismuth(III) Succinate as a Pharmaceutical Substance.
- Source :
-
Russian Journal of Applied Chemistry . Jul2021, Vol. 94 Issue 7, p911-919. 9p. - Publication Year :
- 2021
-
Abstract
- Reactions of solid trihydroxopentaoxohexabismuth(III) pentanitrate trihydrate [Bi6O5(OH)3](NO3)5·3H2O and monoclinic bismuth oxide α-Bi2O3 with a succinic acid solution were studied with the aim of preparing a pharmaceutical substance, basic bismuth succinate С2Н4(СООBiO)2, meeting high purity requirements concerning the content of impurity metals. A procedure for preparing basic bismuth(III) succinate was suggested; it involves hydrolytic treatment of a process solution of bismuth in nitric acid to obtain high-purity [Bi6O5(OH)3](NO3)5·3H2O, its treatment with a NaOH solution to obtain finely crystalline α-Bi2O3, and the subsequent reaction of bismuth oxide with a succinic acid solution. The product composition was confirmed by X-ray diffraction, chemical analysis, IR and Raman spectroscopy, and thermal gravimetric analysis; the content of impurity metals was determined by the atomic absorption method. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10704272
- Volume :
- 94
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Russian Journal of Applied Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 152813821
- Full Text :
- https://doi.org/10.1134/S1070427221070077