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Preparation and evaluation of doxorubicin-luminespib co-loaded multivesicular liposomes.
- Source :
-
Journal of Chinese Pharmaceutical Sciences . Sep2021, Vol. 30 Issue 9, p736-742. 7p. - Publication Year :
- 2021
-
Abstract
- A combinational therapeutic system that simultaneously administrates various pathways is preferred for anti-cancer treatment. In the present study, we successfully constructed a co-delivery system, multivesicular liposomes (MVLs) co-encapsulating doxorubicin (DOX) and luminespib (AUY922). A simple and accurate dual-wavelength spectrophotometric method was established for the determination of DOX and AUY922 in liposomal formulation. MVL-loading drugs were prepared by a multi-emulsion solvent evaporation method, which exhibited excellent physicochemical properties, such as particle size of 3-8 μm and high entrapment efficiency above 95% for DOX and 73% for AUY922. The synergetic cytotoxic effect for these two drugs was evaluated in MDA-MB-231 cells. The in vitro antitumor studies demonstrated the superior anti-proliferation activity of DOX and AUY922 with a combination index of 0.43, indicating a great synergistic effect. The experimental data suggested that combinational use of DOX and AUY922 within liposomes could be an effective way to develop efficient treatments of cancers. [ABSTRACT FROM AUTHOR]
- Subjects :
- *LIPOSOMES
*DOXORUBICIN
*IN vitro studies
*PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 10031057
- Volume :
- 30
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Journal of Chinese Pharmaceutical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 152836424
- Full Text :
- https://doi.org/10.5246/jcps.2021.09.061