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Serum VEGF and Ang-2 Levels in Infants Before and After Laser Treatment for Retinopathy of Prematurity.
- Source :
-
Fetal & Pediatric Pathology . October 2021, Vol. 40 Issue 5, p407-413. 7p. - Publication Year :
- 2021
-
Abstract
- To investigate VEGF and Ang-2 level changes in the systemic circulation after laser photocoagulation in premature infants with ROP. Methods: Eleven infants (4 girls and 7 boys) had serum levels determined for VEGF and Ang-2, collected 1 day prior to and 7 days after ROP laser therapy. Serum levels of VEGF and Ang-2 were quantified by enzyme-linked immunosorbent assay (ELISA). Results: Serum VEGF levels were significantly lower at 7 days after laser therapy compared to that at 1 day prior to laser therapy (p = 0.045). Serum Ang-2 levels increased significantly at 7 days after laser therapy compared with that at 1 day prior to laser therapy (p = 0.046). Conclusions: Serum VEGF levels in patients with ROP were suppressed and Ang-2 levels elevated significantly after laser therapy. The results suggest that changes in VEGF and Ang-2 serum levels may reflect regression and treatment of ROP. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15513815
- Volume :
- 40
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Fetal & Pediatric Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 152850710
- Full Text :
- https://doi.org/10.1080/15513815.2020.1721625