Daytime diurnal curve comparison between the fixed combinations of latanoprost 0.005%/timolol maleate 0.5%and dorzolamide 2%/timolol maleate 0.5%.

PURPOSE:The diurnal efficacy and safety of the fixed combinations of latanoprost/timolol given once daily vs dorzolamide/timolol given twice daily in primary open-angle glaucoma or ocular hypertensive patients. DESIGN:A double-masked, two-centre, crossover comparison. RESULTS:In 33 patients, the mean diurnal IOP (0800-2000, measured every 2?h) for latanoprost/timolol fixed combination was 17.3±2.2?mmHg and for dorzolamide/timolol, the fixed combination was 17.0±2.0?mmHg (P=0.36). Additionally, there was no statistical difference for individual time points following a Bonferroni correction. A bitter taste was found more frequently with the dorzolamide/timolol fixed combination (n=6) than the latanoprost/timolol fixed combination (n=0) (P=0.040), while the latanoprost/timolol fixed combination demonstrated more conjunctival hyperaemia (n=9) than the dorzolamide/timolol fixed combination (n=2) (P=0.045). One patient was discontinued early from the dorzolamide/timolol fixed combination due to elevated IOP. CONCLUSION:This study suggests that the daytime diurnal IOP is not statistically different between the dorzolamide/timolol fixed combination and latanoprost/timolol fixed combination in primary open-angle glaucoma and ocular hypertensive patients.Eye (2004) 18, 1264-1269. doi:10.1038/sj.eye.6701446 Published online 25 June 2004 [ABSTRACT FROM AUTHOR]