Profiling of DNA damage and repair pathways in small cell lung cancer reveals a suppressive role in the immune landscape.

To dissect which DDR pathways correlated with the immune landscape of SCLC, we performed correlation analysis between different DDR pathways and the different immune contents in SCLC patients. Furthermore, in multiple-plex immunofluorescence staining of RAD51/CD4/CD8/CD20/Foxp3 in SCLC tissue microarray, SCLC tissues with increased RAD51 staining showed decreased CD8+ lymphocyte infiltration (Supplementary Fig. E, qPCR array analysis of differentially expressed DNA damage and repair genes in SCLC cell versus BEP2D cells and NSCLC cells. [Extracted from the article]