A Comparative Study to Evaluate Safety of Antidiabetic Drugs and Its Complications; Emphasis on the Adverse Drug Reaction in Patients Visiting Tertiary Center and Private Clinic.

Introduction: Adverse drug reaction is defined by WHO as any response to a drug which is noxious and unintended, and which occurs at doses used in man for the prophylaxis, diagnosis or therapy of disease or for the modification of physiological function. Material and Methods: It was comparative, prospective and cohort study. The study was conducted at SMBT Medical Institute and Research Centre Dhamangaon Nashik and private Diabetic clinic. Group A: SMBT Medical Institute and Research Centre Dhamangaon Nashik. Group B: Private Diabetic clinic. All suspected ADRs were initially assessed by the Consultant Incharge - Diabetes Clinic and subsequently the information was collected and analyzed by the pharmacologists for causality assessment. Result: All the reported ADRs i.e. 22 (100%) were of type A reactions which are predictable. On the other hand, in Private clinic, a total of 18 patients of various age groups, belonging to either gender suffered from the adverse drug reactions. Among them, 17 (94.4%) cases were of type A reactions which are predictable. Only 1 (5.55%) suffered from Type B reaction. During the study period, 22 cases of adverse drug reactions were reported in Tertiary care hospital, out of which all (100 %) were of predictable type. The most commonly occurring ADR were hypoglycaemia was the most common ADR observed accountable 8 (36.3%). The most commonly occurring ADRs were hypoglycaemia was the most common ADR observed accountable 7 (38.8%) followed by Abdominal pain, Dizziness, Pedal edema. The percentages of other adverse drug reactions were comparatively less in Group B. Conclusion: ADRs are drug related problems which is considered as important drawback for drug safety. The spontaneous reporting used in study allowed the detection and characterization of ADRs. [ABSTRACT FROM AUTHOR]