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Improved gut microbiota features after the resolution of SARS‑CoV‑2 infection.
- Source :
-
Gut Pathogens . 10/16/2021, Vol. 13 Issue 1, p1-4. 4p. - Publication Year :
- 2021
-
Abstract
- Background: The severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) has a tropism for the gastrointestinal tract and several studies have shown an alteration of the gut microbiota in hospitalized infected patients. However, long-term data on microbiota changes after recovery are lacking. Methods: We enrolled 30 patients hospitalized for SARS‑CoV‑2-related pneumonia. Their gut microbiota was analyzed within 48 h from the admission and compared with (1) that of other patients admitted for suspected bacterial pneumonia (control group) (2) that obtained from the same subject 6 months after nasopharyngeal swab negativization. Results: Gut microbiota alpha-diversity increased 6 months after the resolution of SARS-CoV-2 infection. Bacteroidetes relative abundance was higher (≈ 36.8%) in patients with SARS-CoV-2, and declined to 18.7% when SARS-CoV-2 infection resolved (p = 0.004). Conversely, Firmicutes were prevalent (≈ 75%) in controls and in samples collected after SARS-CoV-2 infection resolution (p = 0.001). Ruminococcaceae, Lachnospiraceae and Blautia increased after SARS-CoV-2 infection resolution, rebalancing the gut microbiota composition. Conclusion: SARS-CoV-2 infection is associated with changes in the gut microbiome, which tend to be reversed in long-term period. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SARS-CoV-2
*COVID-19
*GUT microbiome
*INFECTION
Subjects
Details
- Language :
- English
- ISSN :
- 17574749
- Volume :
- 13
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Gut Pathogens
- Publication Type :
- Academic Journal
- Accession number :
- 153077913
- Full Text :
- https://doi.org/10.1186/s13099-021-00459-9