自修复水凝胶在骨组织工程中的应用.

BACKGROUND: Self-healing hydrogels are scaffold materials with superior self-healing capability and biocompatibility, and are widely used in bone tissue engineering. OBJECTIVE: To introduce the gelatin mechanism and composition of self-healing hydrogels and summarize their applications in bone tissue engineering. METHODS: The first author searched both Chinese and English articles with key words "self-healing hydrogels; bone tissue engineering; bone regeneration" on CNKl, Wanfang, VIP, PubMed, Embase and Web of Science databases published from 2000 to 2020. Totally 69 eligible articles were selected for review. RESULTS AND CONCLUSION: The gelation mechanisms of self-healing hydrogels include dynamic covalent bonds, supramolecular bonds and multi-mechanism cross-links. Self-healing hydrogels can be composed of natural polymers, synthetic polymers and nanocomposites. Self-healing hydrogels have been found to be applied in bone tissue engineering through scaffold modification as stem cells delivery vehicle. The application of self-healing hydrogels in bone tissue engineering can be broaden by enhancing the mechanical properties of the hydrogel while maintaining its self-healing capability. Additionally, the specific mechanism for better superiority of self-repairing hydrogels over traditional hydrogels in bone tissue engineering is still unclear. [ABSTRACT FROM AUTHOR]