Effect of rare earth element lanthanum on lipid deposition and Wnt10b signaling in the liver of male zebrafish.

• La accumulation affects nutrient elements content in the liver of zebrafish. • La affects hepatic lipid deposition via decreasing FAS, ACC, and ACL activity. • La affects wnt10b signaling pathway in the liver of zebrafish. • La may inhibit hepatic lipid deposition via wnt10b signaling in zebrafish. This paper investigates the effect of lanthanum (La) on lipid deposition and Wnt10b signaling in the liver of male zebrafish with exposure of 0, 10, 20, and 30 μmol/L La. It suggests that La can be accumulated in liver, and its treatments decrease the activities and gene expression of enzymes related to fatty acid synthesis. The levels of total cholesterol (TC), triglyceride (TG), and nonesterified fatty acids (NEFA) as well as the size of lipid droplets are decreased by La treatments. Moreover, La treatments affect the composition of fatty acids and the content of nutrient elements. Meanwhile, they also induce the gene expression of wnt10b, β-catenin, pparα , and pparγ , but inhibit gsk-3β gene expression in liver. Further study on the result of wnt10b gene interference shows that Wnt10b/β-catenin signaling plays a crucial role in the regulatory process of hepatic lipid deposition. Taken together, our observations suggest that La accumulation affects lipid deposition in the liver of male zebrafish, and Wnt10b signaling pathway may be involved in this process. [ABSTRACT FROM AUTHOR]