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SYNTHESIS AND ANTICANCER ACTIVITY AGAINST RETINOBLASTOMA OF NOVEL Zn(II) AND Co(II) COMPLEXES.
- Source :
-
Journal of Structural Chemistry . Sep2021, Vol. 62 Issue 9, p1464-1471. 8p. - Publication Year :
- 2021
-
Abstract
- A binucleating Schiff base ligand 2-methoxy-6-(iminomethyl)phenol (HL) and two new M(II) complexes [Zn4L4(N3)4](H2O)2 (1) and [Co4L4Cl4] (2) are synthesized. These metal complexes are characterized using various physicochemical techniques, e.g. elemental analyses and single crystal X-ray diffraction. Furthermore, both CCK-8 assay and cell colony formation results indicate that the inhibitory activity of compound 1 against Y79 retinoblastoma cancer cells is stronger than that of compound 2. In addition to this, we also reveal that compound 1 can significantly increase the ROS accumulation in Y79 retinoblastoma cancer cells, which is higher than that in the group treated with compound 2. All the results above suggest a stronger anticancer activity of compound 1 compared to compound 2 and that it has the potential of being a novel candidate for retinoblastoma cancer treatment. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00224766
- Volume :
- 62
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Journal of Structural Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 153222767
- Full Text :
- https://doi.org/10.1134/S002247662109016X