SYNTHESIS AND ANTICANCER ACTIVITY AGAINST RETINOBLASTOMA OF NOVEL Zn(II) AND Co(II) COMPLEXES.

A binucleating Schiff base ligand 2-methoxy-6-(iminomethyl)phenol (HL) and two new M(II) complexes [Zn4L4(N3)4](H2O)2 (1) and [Co4L4Cl4] (2) are synthesized. These metal complexes are characterized using various physicochemical techniques, e.g. elemental analyses and single crystal X-ray diffraction. Furthermore, both CCK-8 assay and cell colony formation results indicate that the inhibitory activity of compound 1 against Y79 retinoblastoma cancer cells is stronger than that of compound 2. In addition to this, we also reveal that compound 1 can significantly increase the ROS accumulation in Y79 retinoblastoma cancer cells, which is higher than that in the group treated with compound 2. All the results above suggest a stronger anticancer activity of compound 1 compared to compound 2 and that it has the potential of being a novel candidate for retinoblastoma cancer treatment. [ABSTRACT FROM AUTHOR]