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A new indolizinium alkaloid from marine-derived Streptomyces sp. HNA39.
- Source :
-
Journal of Asian Natural Products Research . Sep 2021, Vol. 23 Issue 9, p913-918. 6p. - Publication Year :
- 2021
-
Abstract
- A new indolizinium alkaloid, named as cyclizidine J (1), was identified from Gause's liquid fermentation of marine-derived Streptomyces sp. HNA39. Its structure was elucidated by extensive NMR spectroscopic methods, HRESIMS data, and ECD calculations. To our best knowledge, compound 1 was a unique cyclizidine-type alkaloid that contain a chlorine atom substituted at position C-8. Unfortunately, biological evaluation of 1 exhibited no active against PC-3 cancer cell line, BRD4, and ROCK2 protein kinase. [ABSTRACT FROM AUTHOR]
- Subjects :
- *EXPERIMENTAL design
*PROTEIN kinases
*HIGH performance liquid chromatography
*SEQUENCE analysis
*ALKALOIDS
*NUCLEAR magnetic resonance spectroscopy
*MASS spectrometry
*TOXICITY testing
*DESCRIPTIVE statistics
*RESEARCH funding
*CELL lines
*MOLECULAR structure
*CHROMATOGRAPHIC analysis
*PROSTATE tumors
*GRAM-positive bacteria
*FERMENTATION
Subjects
Details
- Language :
- English
- ISSN :
- 10286020
- Volume :
- 23
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 153247240
- Full Text :
- https://doi.org/10.1080/10286020.2020.1799987