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Radiation-Induced Emesis (RIE) in Extended-Field Radiotherapy for Gynecological Malignancies: Dosimetric and Non-Dosimetric Factors.
- Source :
-
Current Oncology . Oct2021, Vol. 28 Issue 5, p3602-3609. 8p. 4 Charts, 2 Graphs. - Publication Year :
- 2021
-
Abstract
- Radiation-induced emesis (RIE) is usually noted during abdominal-pelvic radiotherapy. In gynecological malignancies, it is usually noted in para-aortic but not whole-pelvic irradiation. Irradiated small bowel (SB) may be associated with RIE. The significance of SB dosimetry remains unclear. Dosimetric and non-dosimetric factors were evaluated and correlated with RIE in 45 patients with gynecological malignancies undergoing extended-field radiotherapy (EFRT) (median 45 Gy) from 2006 to 2021. Early-onset RIE (within 72 h after the first fraction of EFRT) was noted in 10 of 12 RIE patients. RIE was significantly associated with the SB mean dose. The RIE rates were 58.3% and 15.2% (p = 0.007) in patients with a low (<63%) and high (≥63%) SB mean dose. Logistic regression revealed that the SB mean dose remained the independent factor of overall RIE (p = 0.049) and early-onset RIE (p = 0.014). Therefore, constraint of the SB mean dose limited to less than 63% of the prescribed dose is suggested to decrease RIE. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 11980052
- Volume :
- 28
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Current Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 153254522
- Full Text :
- https://doi.org/10.3390/curroncol28050308