Back to Search
Start Over
The genetic source tracking of human urinary exosomes.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America . 10/26/2021, Vol. 118 Issue 43, p1-3. 3p. - Publication Year :
- 2021
-
Abstract
- The genetic origins of nanoscale extracellular vesicles in our body fluids remains unclear. Here, we perform a tracking analysis of urinary exosomes via RNA sequencing, revealing that urine exosomes mostly express tissue-specific genes for the bladder and have close cell-genetic relationships to the endothelial cell, basal cell, monocyte, and dendritic cell. Tracking the differentially expressed genes of cancers and corresponding enrichment analysis show urine exosomes are intensively involved in immune activities, indicating that they may be harnessed as reliable biomarkers of noninvasive liquid biopsy in cancer genomic diagnostics and precision medicine. [ABSTRACT FROM AUTHOR]
- Subjects :
- *EXTRACELLULAR vesicles
*EXOSOMES
*RNA sequencing
*CANCER genes
*DENDRITIC cells
Subjects
Details
- Language :
- English
- ISSN :
- 00278424
- Volume :
- 118
- Issue :
- 43
- Database :
- Academic Search Index
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 153307511
- Full Text :
- https://doi.org/10.1073/pnas.2108876118