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Associations Between Human Milk Oligosaccharides at 1 Month and Infant Development Throughout the First Year of Life in a Brazilian Cohort.
- Source :
-
Journal of Nutrition . Nov2021, Vol. 151 Issue 11, p3543-3554. 12p. - Publication Year :
- 2021
-
Abstract
- <bold>Background: </bold>Human milk oligosaccharides (HMOs) are unconjugated glycans associated with infant health and development.<bold>Objectives: </bold>To investigate the associations between HMO concentrations at 1 month and infant development throughout the first year of life.<bold>Methods: </bold>A prospective cohort of Brazilian women between 18-40 years of age and their infants was studied from baseline (between 28-35 gestational weeks) and followed at 1 (n = 73), 6 (n = 51), and 12 months (n = 45). A total of 19 HMOs were quantified by HPLC with fluorescence detection. Infant development was evaluated by the Brazilian Ages and Stages Questionnaire. A directed acyclic graph was used to define the minimally sufficient adjustment (gestational age at birth, gestational weight gain, prepregnancy BMI, maternal age, parity, and the mode of breastfeeding at 1 month). Cox regression models with HRs and Benjamini-Hochberg multiple corrections were performed to estimate associations of HMOs with the cumulative risk of inadequate development for 5 developmental domains or for ≥2 developmental domains in all women and in the subset of secretor women (defined as the presence or near absence of 2'-fucosyllactose and lacto-N-fucopentaose I).<bold>Results: </bold>The multivariate models with multiple corrections revealed an inverse association between lacto-N-tetrose (LNT) and the risk of inadequate development for personal-social skills (0.06; 95% CI: 0.01-0.76) and for ≥2 developmental domains (0.06; 95% CI: 0.01-0.59). The secretor mothers analysis also showed inverse associations with slightly different results for personal-social skills (0.09; 95% CI: 0.02-0.84) and ≥2 developmental domains (0.05; 95% CI: 0.01-0.70).<bold>Conclusions: </bold>Higher concentrations of LNT HMOs in Brazilian women are associated with their infants being less likely to be at risk of inadequate development for personal-social skills or for ≥2 developmental domains during the first year of life. [ABSTRACT FROM AUTHOR]
- Subjects :
- *INFANTS
*INFANT development
*BREAST milk
*OLIGOSACCHARIDES
*INFANT formulas
*DIRECTED acyclic graphs
*MATERNAL age
*RESEARCH
*SOCIAL participation
*CHILD development
*RESEARCH methodology
*SOCIAL networks
*EVALUATION research
*COMPARATIVE studies
*PSYCHOLOGICAL tests
*BREASTFEEDING
*QUESTIONNAIRES
*RESEARCH funding
*LONGITUDINAL method
Subjects
Details
- Language :
- English
- ISSN :
- 00223166
- Volume :
- 151
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Journal of Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 153411098
- Full Text :
- https://doi.org/10.1093/jn/nxab271