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Mouse-adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge.
- Source :
-
PLoS Biology . 11/4/2021, Vol. 19 Issue 11, p1-21. 21p. 3 Graphs. - Publication Year :
- 2021
-
Abstract
- The emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a pandemic causing significant damage to public health and the economy. Efforts to understand the mechanisms of Coronavirus Disease 2019 (COVID-19) have been hampered by the lack of robust mouse models. To overcome this barrier, we used a reverse genetic system to generate a mouse-adapted strain of SARS-CoV-2. Incorporating key mutations found in SARS-CoV-2 variants, this model recapitulates critical elements of human infection including viral replication in the lung, immune cell infiltration, and significant in vivo disease. Importantly, mouse adaptation of SARS-CoV-2 does not impair replication in human airway cells and maintains antigenicity similar to human SARS-CoV-2 strains. Coupled with the incorporation of mutations found in variants of concern, CMA3p20 offers several advantages over other mouse-adapted SARS-CoV-2 strains. Using this model, we demonstrate that SARS-CoV-2–infected mice are protected from lethal challenge with the original Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), suggesting immunity from heterologous Coronavirus (CoV) strains. Together, the results highlight the use of this mouse model for further study of SARS-CoV-2 infection and disease. Studying cross-protection from different coronaviruses is important to inform the research for a universal vaccine. This study uses a mouse-adapted SARS-CoV-2 strain to show that it confers protection from SARS-CoV challenge, suggesting possible immunity from heterologous challenge following natural infection. [ABSTRACT FROM AUTHOR]
- Subjects :
- *COVID-19
*SARS-CoV-2
*SARS disease
*SARS virus
*MICE
*LABORATORY mice
*VIRUS diseases
Subjects
Details
- Language :
- English
- ISSN :
- 15449173
- Volume :
- 19
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- PLoS Biology
- Publication Type :
- Academic Journal
- Accession number :
- 153411180
- Full Text :
- https://doi.org/10.1371/journal.pbio.3001284