Voluntary running of defined distances alters bone microstructure in C57BL/6 mice fed a high-fat diet.

The article discusses a study on voluntary running of defined distances among mice fed with a high-fat diet (HFD). It states that running is positively correlated with bone volume fraction (BV/TV) and a higher structure model index (SMI) in vertebrae, and that quantitative voluntary running improves bone microstructure through its attenuation of bone resorption in the mice fed with a HFD. Also noted are findings which show that voluntary running improves bone quality in such young mice.