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Improved Synthesis of First Cell-Permeable Allosteric PTPRZ Inhibitor NAZ2329.
- Source :
-
Russian Journal of General Chemistry . Oct2021, Vol. 91 Issue 10, p2095-2100. 6p. - Publication Year :
- 2021
-
Abstract
- NAZ2329 is the first cell-permeable small molecular allosteric inhibitor of protein tyrosine phosphatase receptor–type Z (PTPRZ), which was considered as a new potential molecular target for drug development in glioblastoma. A facile and high-efficient synthesis of NAZ2329 was developed by a straight-forward strategy starting from key ethoxy benzyl bromide intermediate obtained from commercially available 4-(trifluoromethyl)phenol. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10703632
- Volume :
- 91
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Russian Journal of General Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 153455485
- Full Text :
- https://doi.org/10.1134/S1070363221100273