无创正压通气治疗重症社区获得性肺炎临床疗效和预后影响.

Objective: To investigate the effect of noninvasive positive pressure ventilation on the treatment effect and prognosis of severe community-acquired pneumonia. Methods: Taking 80 patients with SCAP admitted to our hospital from July 2018 to February 2020 as the research object, they were divided into non-invasive group and routine group by random number method, 40 cases each. Both groups of patients received conventional treatment after admission, and the non-invasive group received NIPPV treatment based on conventional treatment. The patient's body temperature, respiration, blood pressure, heart rate, PaCO2, PaO2/FIO2, endotracheal intubation rate, fatality rate, and ICU hospitalization days were recorded before and after treatment. The serum PCT, CRP and suPAR levels on the first, third and seventh days of the patients' admission were tested. Results: 1 h and 24 h after treatment, the patients in the noninvasive group had significant improvement in respiration, heart rate, PaCO2, PaO2/FIO2 and PH (P<0.05), It shows that NIPPV can significantly improve the gas exchange in the lungs of patients, slow down the respiratory rate, increase oxygen and index, and reduce the partial pressure of carbon dioxide. On the first day, there was no significant difference in the levels of PCT, CRP and suPAR between the two groups (P>0.05). Compared with the first day, the PCT, CRP and suPAR levels on the third and seventh days of the two groups of patients were significantly reduced (P<0.05). Compared with the conventional group, the PCT on the third and seventh days of the noninvasive group, CRP and suPAR levels were significantly reduced (P<0.05). Compared with the conventional group, there was no statistically significant difference in the intubation rate, ICU hospital stay, and mortality in the noninvasive group (P>0.05), but they all decreased to a certain extent. Conclusion: NIPPV can significantly improve the expiratory condition of SCAP patients, reduce serum PCT, CRP and suPAR levels, have a certain effect on reducing the rate of tracheal intubation, shortening the length of hospital stay in ICU and reducing the mortality of patients. [ABSTRACT FROM AUTHOR]